The Game is a popular(really?) game played by anyone who is in this game. There are a lot variations but you can just follow the Wikipedia rules.

Since everyone is in this game, we should come up with a rigor definition of everyone.
Any organism that is currently alive and homo sapien.

Because the condition for losing is to think of the game, there have to be some definition of thinking.
What is thinking? how can we define if someone is thinking about something? I don't know. You are the one to judge.

Losing is think of the game, but should they be a gap between losing? What if I continuously thinking about the game for 10 hours, is that only one lose?
People come up with different gaps. Like 30 minute since last lose is the same time.

The loser have to announce he is lost. In any form, include spam.
Is there a way aware of the game but never lose?
Yes, in theory. But in practice no.
Some people have suggested that one can isolate himself in a place where no human can contact, so there is no way a outside influence can make him lose.
But a common man will ask himself why is he here, and then he will think of the game and lose, all the time.

While the primary goal is hard to achieve. Making other people lose are quite easy. All they have to know, is to aware that about the game.
Advertisement!
Use all the marketing skill you are aware of.
Facebook wall posts
Discussion groups
Forum signatures
Spam
Tatoos
Blog posts
School Newspaper hidden message
Super bowl ads
and of course, spam.

What's the point of this game?
Nothing...
But there might be some mathematical model hidden worth investigating... Anyone want to suggest one?

Problems
more philosophical + mathematical + deep questions I come up with when I have nothing else to do...
I'm enrolled in The Game without my knowledge, is that still enrollment?
Does I have a free will?
if I don't, why don't I?
If I think I'm not playing the game, am I still playing the game?
Is your mom losing The Game?
Why if someone else define something, I have to be restricted by their definition?
Is freedom subjective or objective?
Who will win this presidential election?
Is free will really free will if it's controlled by the outside?
Is life subjective or objective? If people want to win, why do they post stuff like this?
Does the original creator imagined this?
Is he still alive and using this as a way to test human psychology?
Is he LOLing?
Is he a communist? is he Mao? Is the Chinese trying to take over the world? Is Mao still alive but we just believe he is dead? Is Mao who we think he is? Is Mao actually a conspiracy created by the US government? Does China even exist?
What is the consequence of cheating?
Why don't people cheat?
What make people cheat?
Can I get into USAMO?
Does people shout "I lost the game" during tests? Is it allowed? If it's not allowed, is it against the freedom of religion?
Does inform people that one lose is a way of spam?
Is this the world largest spam network?
Will this game ever be forgotten? ...in bed?
What's the possibility that no one in the world ever remembers this game?
Can other organisms join this game?
Is lose really bad? Is win always the best goal?
If win is impossible, is lose really means anything? or should we redefine win?
Is Latex the best material for condoms?
Why should anyone lose?
Can't everyone just win?
Can dead people still have minds?
What happens if one change the word "lose" to "win"?
What sociality impact would it create?
Am I in the Matrix?
What if both game present at the same time?
What if one create -(The Game), where think of the game wins?
What if think of -(The Game) will also considered lose for The Game?
What if there is a constant amount of time required to think of The Game to lose once?
What if that is not a constant but a variable?
what is more important? winning the win able one or not lose the lose able one?
What if there is more states than just win and lose?
what if there is n games create win situation and m games create lose situation when n and m have what property create people tend to favor the winning instead of losing?
If each of those game have different weights, does individual game score matters to people or just the combined weighted average?
What's for dinner?
What if it become a point system?
Making other people lose you get point and if other loses, they lose point?
How should the points be added?
Adding constant points?
or should it add points with specific property?
Should it only use addition?
Can it use w/e other function out there?
Can the points be complex or even higher extension of numbers?
Can the point be vectors, matrix or even tensors?
Is Facebook behind all these? BTW Peter and Pelle if you are reading this... Get a Facebook!
Is it true that the professor who taught Math 254A course in MIT become immortal?
Can there be randomness in the game? for example throw a dice and if it land 6 then no point is subtracted?
What if each player have an armor points?
How can player gain armor points?
and a dice roll below the armor points can get armor save, where their armor get removed and they points get lowered down?
Should the player chose when to use the armor save?
Can this game prove logic?
When should a player use a armor save if he can make the choice?
Does math major get laid more often than theoretical physic majors in college? If so, why does math majors get laid more often than theoretical physic majors in college?
Can we establish some rule that can use all humans who play this game part of a huge calculator?
If so, how to distribute it and how to make these plays generate information, exchange information and in the end make the people who cares about these information get these information?
Is this calculator a Universal Turing Machine?
Can it in the end create a mind control system?
If people are mind controlled, when they think of the game, do they still lose?
If it's a mind control system, how to break out of it?
Can one inside the mind control system manipulate the system?
If one can, how to prevent them not to manipulate the system?
Can I use this system to rule the world?...in bed?
Did anyone read the "evilplan" word file in my flash drive?
Does The Game make sense at all?

Endless of questions there...this is such a provocative game of mind...
Someone, answer me at least a few of them.
I will do research too.